
New Delhi (India), December 13: Bone Marrow Transplantation (BMT) from a donor (Allogeneic BMT) is possibly the most challenging procedure in modern medicine, which has evolved over the last 50 years, curing millions of patients suffering from blood diseases. Both malignant (leukemia/lymphoma/myeloma) and non-malignant (thalassemia/sickle cell anemia/aplastic anemia/ primary immunodeficiencies) however, the success of BMT is incumbent upon finding successful immunological compatibility between the patient and the donor- called matching of HLA or immunological signature, which is inherited from the parents and varies from person to person. There is a 25% chance of two siblings being completely HLA-matched with each other, which basically means that 3 out of 4 patients requiring a BMT would not find a compatible donor.
The question often asked is why an unrelated third person cannot be the donor! The answer lies in the fact that the immunological signature or HLA is extremely variable, and the chance of 2 random persons to match with each other is less than one in a million. While this problem has been largely addressed in Europe and America, for the Caucasian people, with the creation of large unrelated donor registries, where 3 out of 4 Caucasians can find a completely HLA-Matched Unrelated Donor (MUD). This is large because of the very conserved genetic pool of the population, which is not true for a country like India, where thousands of different ethnic races inhabit. The solution for such patients lies in using HLA half-matched or Haploidentical family donors (not unrelated). Haploidentical BMT is one of the most difficult forms of BMT, and no Indian centre performed such transplants in 2010, when Dr Suparno Chakrabarti first initiated Haploidentical BMT program in India.
Dr Suparno Chakrabarti, an alumnus of PGI, Chandigarh, who initiated the Clinical Hematology program at the institute in 1995, returned to India in 2010. He had left for the UK in 1998 and spent 12 years in both clinical and basic research in the field of BMT, initially as a Research Fellow and subsequently as a faculty. Several paradigm shifts happened in the field of BMT during this time, and Dr Chakrabarti made an immense contribution to the field with several path-breaking research. However, his yearning to contribute to his own country brought him back to India. The last ten years were no less significant in terms of his contribution to the field of BMT and immunology. Dr Sarita Rani Jaiswal joined him in 2011 as a trainee at a premier healthcare centre in Kolkata, where the first BMT Centre of eastern India was created.
Dr Chakrabarti had an enormous task in hand, having initiated the most difficult type of BMT for the first time in India, with little support from the institution and otherwise. He was criticized by many at that time for indulging in such a high-risk procedure. But the initial cohort of patients all had very advanced blood cancers without any other treatment options. Dr Sarita Jaiswal trained under him for 3 years before going abroad and training under the pioneers in the field of Haploidentical BMT in Italy and Seattle, USA.
In view of an indifferent attitude of administration, colleagues and the Bengali population overall, Dr Chakrabarti decided to move his base to Delhi. Dr Sarita Jaiswal, being true to the mission of her mentor, joined him at Dharamshila (Narayana) Hospital in 2014, where Dr Suversha Khanna, the founder-promoter of the hospital and Mr Anil Kumar, the outgoing President of the trust, helped them create a true ecosystem for flourishing in both clinical and basic research.
With only 10-20% survival for Haploidentical BMT in 2012-13, Dr Chakrabarti and Dr Jaiswal invested in extensive research along with the clinical work in Delhi. The rest is now history. Currently, in over 150 Haploidentical BMT carried out between 2015-2021, the survival stands at over 80% in both malignant and non-malignant disorders. Dr Jaiswal had made oral presentations every year between 2015-2021 in scientific conferences in Europe and USA. Their innovations in the field of Haploidentical BMT had researchers in the USA adapt their approach. While this has not been an easy journey, the will, dedication, and honesty paid off at the end.
Both Dr Jaiswal and Dr Chakrabarti rue about the fact that only a handful patients are benefitting from their path-breaking work. Most of the country remains ignorant about the scientific breakthroughs which are happening in their own backyard. They do not have the academic, financial, or political patronage to leverage their achievements for the benefit of the millions who need it. Despite all these limitations, they have not given up. In the memory of his late mother, Dr Chakrabarti started the MANASHI CHAKRABARTI FOUNDATION, which was aimed at supporting research and treatment for children with Blood Diseases. They have initiated a Comprehensive Care Centre for Thalassemia and Sickle Cell Anemia at Dharamshila Narayana Hospital. They have been joined in their endeavour by Dr Nivedita Singh, an administrator by profession, who had been a part of their journey through the rough times. Many young doctors have also joined hands to form a platform called BLOODSRUS, under the auspices of MCF, where they are ready to provide comprehensive service for blood diseases to all those who have been deprived of such care until now. The country and its people should utilise this opportunity and grab the change from overwhelming private and indifferent public healthcare.
Receive and send emails through your temporary messaging system. Use our webmail or your favorite email software with our absolutely free disposable email. temp mail
This post is genuinely a good one it assists new the web viewers, who are wishing for blogging.
Hi there, I log on to your blogs daily. Your writing style is witty,
keep doing what you’re doing!
Hi there! This article couldn’t be written much better!
Looking through this post reminds me of my previous roommate!
He always kept preaching about this. I will forward this article to him.
Fairly certain he’s going to have a great read. Many thanks for sharing!
I’m truly enjoying the design and layout of your website.
It’s a very easy on the eyes which makes it much more pleasant for me to come here and visit more
often. Did you hire out a developer to create your theme?
Great work!
I’ve been browsing online more than 2 hours today, yet I
never found any interesting article like yours. It is pretty worth enough for me.
In my view, if all website owners and bloggers made
good content as you did, the internet will be a lot more useful than ever before.
Thank you, I’ve just been searching for information approximately this subject for ages and yours is the best I have
found out so far. However, what concerning the conclusion? Are you certain concerning
the source?
I was recommended this website by my cousin. I’m not sure whether this post is written by
him as nobody else know such detailed about my difficulty.
You are incredible! Thanks!
Hard-hitting news | Are you ready ? In search of the news that strikes. Only quality news can be found here. Welcome aboard Q. news
Hello! I could have sworn I’ve been to this website before but after checking through some of
the post I realized it’s new to me. Anyhow, I’m definitely happy I found
it and I’ll be book-marking and checking back frequently!
107090 481896Hey! This is my first comment here so I just wanted to give a quick shout out and say I truly enjoy reading through your articles. Can you suggest any other blogs/websites/forums that cover the same topics? Thanks for your time! 18077
Good day! This is my first comment here so I just wanted to give a quick shout out and say I really enjoy reading through your articles.
Can you suggest any other blogs/websites/forums that cover the same subjects?
Thanks for your time!
Excellent post however I was wondering if you could write a litte more on this
topic? I’d be very grateful if you could elaborate a little bit more.
Cheers!
437258 669031very nice post, i certainly adore this site, maintain on it 769134
Hello mates, its enormous piece of writing on the topic of
educationand fully defined, keep it up all the time.
Does your site have a contact page? I’m having
trouble locating it but, I’d like to send you an e-mail.
I’ve got some recommendations for your blog
you might be interested in hearing. Either way, great site and I look forward to seeing it grow over time.
743901 356839hello, i came in to learn about this subject, thanks alot. will put this internet site into my bookmarks. 465712
398914 227060extremely nice publish, i definitely adore this internet internet site, keep on it 244890
355090 804239Have read a couple of with the articles on your website now, and I genuinely like your style of blogging. I added it to my favorites weblog internet site list and will probably be checking back soon. 48677
I read this post fully about the difference of hottest and previous technologies, it’s awesome article.
Also visit my homepage; 2022
Greetings from Carolina! I’m bored to tears at work so I decided to browse your site on my iphone during lunch break. I enjoy the info you present here and can’t wait to take a look when I get home. I’m surprised at how fast your blog loaded on my phone .. I’m not even using WIFI, just 3G .. Anyhow, excellent blog!
Appreciate it for helping out, superb info. “The health of nations is more important than the wealth of nations.” by Will Durant.
Appreciate it for helping out, good information.
Wow! This could be one particular of the most helpful blogs We have ever arrive across on this subject. Actually Wonderful. I am also an expert in this topic therefore I can understand your hard work.
Thanks for any other great article. The place else may just anyone get that type of information in such an ideal approach of writing? I’ve a presentation subsequent week, and I’m at the look for such information.
Thank you for another informative website. Where else could I get that type of information written in such an ideal way? I’ve a project that I’m just now working on, and I’ve been on the look out for such information.
923163 699699You got a quite outstanding site, Glad I noticed it via yahoo. 429556
There’s noticeably a bundle to know about this. I assume you made sure good points in features also.
I’m not sure exactly why but this web site is loading incredibly slow for me. Is anyone else having this issue or is it a problem on my end? I’ll check back later and see if the problem still exists.
Thanks for the blog post, can you make it so I get an alert email whenever you publish a fresh post?
Hey! Do you use Twitter? I’d like to follow you if that would be ok. I’m definitely enjoying your blog and look forward to new updates.
437067 119650You must participate in a contest for among the very best blogs on the internet. I will recommend this web site! 205660
Wow that was odd. I just wrote an very long comment but after I clicked submit my comment didn’t show up. Grrrr… well I’m not writing all that over again. Anyways, just wanted to say excellent blog!
569260 946360I was examining some of your content material on this internet internet site and I believe this website is rattling instructive! Keep putting up. 454455
362558 292247Hi my friend! I want to say that this post is amazing, good written and consist of approximately all significant infos. Id like to see a lot more posts like this . 811979
Hi , I do believe this is an excellent blog. I stumbled upon it on Yahoo , i will come back once again. Money and freedom is the best way to change, may you be rich and help other people.
103372 381066Hey there! Fantastic post! Please do tell us when we shall see a follow up! 794734
I’ve recently started a web site, the info you offer on this website has helped me greatly. Thanks for all of your time & work. “If you see a snake, just kill it. Don’t appoint a committee on snakes.” by H. Ross Perot.
484583 244844For anybody who is considering about external complications, sometimes be tough amaze those to realize to produce just a single weed in this really flowing typically requires eleven liters concerning gasoline to. dc free mommy weblog giveaways family trip home gardening home power wash baby laundry detergent 991614
823520 843264You might find two to three new levels inside L . a . Weight loss and any one someone is incredibly essential. Initial stage could be real melting away rrn the body. shed weight 914745
Hey there! I’m at work browsing your blog from my new apple iphone! Just wanted to say I love reading your blog and look forward to all your posts! Keep up the superb work!
Wonderful post however I was wondering if you could write a litte more on this subject? I’d be very grateful if you could elaborate a little bit more. Kudos!
Thanks for the sensible critique. Me and my neighbor were just preparing to do a little research on this. We got a grab a book from our area library but I think I learned more clear from this post. I’m very glad to see such magnificent info being shared freely out there.
514516 989108Thank you for the excellent writeup. It in fact was a amusement account it. Appear advanced to far added agreeable from you! Nevertheless, how could we communicate? 996587
Great site. A lot of helpful info here. I am sending it to several friends ans also sharing in delicious. And naturally, thank you for your sweat!
Hi there! This post couldn’t be written any better! Reading through this post reminds me of my previous room mate! He always kept talking about this. I will forward this article to him. Pretty sure he will have a good read. Thank you for sharing!